Not ever ridden with the 2CTs, but have an FZ1 I've been running Road 2's on and I gotta say, they get huge mileage out of the tires.
The last set I got 13,000 miles out of the front, and 9000 miles on the rear.
And that was with "spirited" riding (i.e. no touring pace).
I've had the bike for two years with 258 miles when I bought it.
It now is pushing 26,000 miles and am only on the 2nd set of Road 2's.
The Road 3's are super good in the wet, although more expensive than the Road 2's.
Now you can't expect equivalent handling performance between Road 2/3's and 2CT's.
But I have friends who've done track days on Road 2's with no problem.
I myself currently run Dunlop Q2's on my RC51, but if mileage is a priority, I'd consider Road 2/3's, or equivalent tires from Dunlop, Continental, etc.