Just installed a HealTech quickshifter on my Hyperstrada and it works up and down. I does have a slipper clutch and I think it works better on this bike than the Beemer on downshifts. You don't have to blip but it certainly helps.
As for the gear box life, too early for me to say. I can tell you that Ducati upgraded their gear boxes for their new sport 821 Pani's to deal better with expected quickshifter installation, so there's probably something to your concern. So we'll see. If I break it, I'll fix it...
2004 BMW R1150SR Project Touring Bike (in-work)
2005 Honda RC-51 SP-2 - future track tool
2014 Ducati HyperProject (Hyperstrada)